Exercise Program Improves Functional Capacity and Quality of Life in Uncorrected Atrial Septal Defect-Associated Pulmonary Arterial Hypertension: A Randomized-Control Pilot Study
Annals of Rehabilitation Medicine 2020³â 44±Ç 6È£ p.468 ~ p.480
(Rakhmawati Annis) - Universitas Gadjah Mada/Dr. Sardjito Hospital Faculty of Medicine, Public Health and Nursing Department of Cardiology and Vascular Medicine
(Achmad Indera Noor) - Universitas Gadjah Mada/Dr. Sardjito Hospital Faculty of Medicine, Public Health and Nursing Department of Cardiology and Vascular Medicine
(Hartopo Anggoro Budi) - Universitas Gadjah Mada/Dr. Sardjito Hospital Faculty of Medicine, Public Health and Nursing Department of Cardiology and Vascular Medicine
(Anggrahini Dyah Wulan) - Universitas Gadjah Mada/Dr. Sardjito Hospital Faculty of Medicine, Public Health and Nursing Department of Cardiology and Vascular Medicine
(Arso Irsad Andi) - Universitas Gadjah Mada/Dr. Sardjito Hospital Faculty of Medicine, Public Health and Nursing Department of Cardiology and Vascular Medicine
(Emoto Noriaki) - Kobe University Graduate School of Medicine Department of Internal Medicine
(Dinarti Lucia Kris) - Universitas Gadjah Mada/Dr. Sardjito Hospital Faculty of Medicine, Public Health and Nursing Department of Cardiology and Vascular Medicine
Abstract
Objective: To assess the effect of combined hospital and home-based exercise programs on functional capacity and quality of life (QoL) among uncorrected atrial septal defect-associated pulmonary arterial hypertension (ASD-PAH) patients.
Methods: This study was a randomized controlled trial with uncorrected ASD-PAH patients as the subjects. They were allocated randomly into control and exercise groups. Exercise group subjects performed hospital and home-based exercise programs, completing baseline 6-minute walking test (6MWT) and EQ-5D-3L QoL test (Utility Index and EQ-VAS scores), and were followed up for 12 weeks. The primary outcomes were 6MWT distance and EQ-5D-3L score at week 12. The N-terminal pro B-type natriuretic peptide (NT-proBNP) level was also assessed. A repeated-measure ANOVA was performed to detect endpoint differences over time.
Results: The exercise group contained 20 subjects and control group contained 19. In total, 19 exercise group subjects and 16 control group subjects completed the protocol. The 6MWT distance, Utility Index score, and EQ-VAS score incrementally improved significantly in the exercise group from baseline until week 12, with mean differences of 76.7 m (p<0.001), 0.137 (p<0.001) and 15.5 (p<0.001), respectively. Compared with the control group, the exercise group had significantly increased 6MWT distance and utility index score at week 12. The EQ-VAS score increased in the exercise group at week 12. The NT-proBNP level decreased at week 12 in the exercise group.
Conclusion: Combined hospital and home-based exercise program added to PAH-targeted therapy, improving functional capacity and QoL in uncorrected ASD-PAH patients.
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Heart septal defects, Atrial, Pulmonary arterial hypertension, Exercise therapy, Quality of life, Physical functional performance
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Combined hospital and home-based exercise program added to PAH-targeted therapy, improving functional capacity and QoL in uncorrected ASD-PAH patients.